Italian qualifier Lorenzo Musetti pulled off a second consecutive upset Thursday, beating Japan's Kei Nishikori 6-3, 6-4 in the second round of the Internazionali BNL d'Italia in Rome.
Musetti, an 18-year-old ranked 249th in the world, got past Switzerland's Stan Warwinka in the first round. He became the first Italian teen to get to the third round in Rome since Diego Nargiso accomplished the feat 31 years ago.
Nishikori, 30, reached the 2014 U.S. Open final and was ranked as high as No. 4 in the world the following year.
Musetti saved all five break points he faced and converted two of his six break opportunities.
"It was an incredible match," Musetti said. "I think I played really smart, as he was playing close to the baseline.
"It was different to Wawrinka, they are great champions. I am really happy right now. I felt really good on my forehand from the beginning. I could play more offensively on return, than against Stan."
Next up for Musetti is a matchup with another player who pulled off a second-round upset Thursday, Dominik Koepfer. The 26-year-old German qualifier got past fifth-seeded Gael Monfils of France 6-2, 6-4.
Three other seeded players were ousted Thursday.
France's Ugo Humbert edged seventh-seeded Fabio Fognini of Italy 7-5, 7-6 (4). Serbia's Dusan Lajovic topped 13th-seeded Milos Raonic of Canada 7-6 (3), 4-6, 6-2. Poland's Hubert Hurkacz eliminated ninth-seeded Andrey Rublev of Russia 7-6 (6), 3-6, 6-2.
Eighth-seeded Diego Schwartzman of Argentina beat Australia's John Millman 6-4, 7-6 (1), and 12th-seeded Denis Shapovalov of Canada dumped Spanish qualifier Pedro Martinez 6-4, 6-4.
Shapovalov advanced despite putting just 49 percent of his first serves in play and winning just 38 of 61 service points overall (62 percent). He earned a matchup with Humbert in the third round.
"I have definitely some tougher matches ahead of me, for sure," Shapovalov said. "Hopefully I can keep doing the same thing that I have been doing, because I feel like against these clay-court players the last two rounds, it's worked really well."
The Humbert-Fognini match featured a whopping 11 service breaks in two sets -- including breaks in each of the first six games. The players then each held serve until a Humbert break at 5-6 sealed the set.
Following two breaks apiece in the second set, Humbert captured the final four points in the tiebreaker to take the match.
"I am very happy to win today against Fabio, a great player," Humbert said.
--Field Level Media